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Progressive cGVHD

MedGen UID:
761571
•Concept ID:
C3539781
•
Disease or Syndrome
Synonyms: Progressive chronic Graft vs Host Disease; Progressive Disease

Definition

Failure of therapy to control chronic Graft versus Host Disease (cGVHD). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProgressive cGVHD

Professional guidelines

PubMed

Extracorporeal photopheresis as first-line strategy in the treatment of acute graft-versus-host disease after hematopoietic stem cell transplantation: A single-center experience.
Sestili S, Eder S, Belhocine R, Dulery R, Battipaglia G, Brissot E, Mediavilla C, Banet A, van de Wyngaert Z, Paviglianiti A, Ledraa T, Bonin A, Mohty M, Malard F
Cytotherapy 2020 Aug;22(8):445-449. Epub 2020 May 18 doi: 10.1016/j.jcyt.2020.03.003. PMID: 32434750
Changes in Immunosuppressive Treatment of Chronic Graft-versus-Host Disease: Comparison of 2 Surveys within Allogeneic Hematopoietic Stem Cell Transplant Centers in Germany, Austria, and Switzerland.
Wolff D, Hilgendorf I, Wagner-Drouet E, Jedlickova Z, Ayuk F, Zeiser R, Schäfer-Eckart K, Gerbitz A, Stadler M, Klein S, Middeke JM, Lawitschka A, Winkler J, Halter J, Holler E, Kobbe G, Stelljes M, Ditschkowski M, Greinix H
Biol Blood Marrow Transplant 2019 Jul;25(7):1450-1455. Epub 2019 Mar 13 doi: 10.1016/j.bbmt.2019.03.003. PMID: 30876928

Recent clinical studies

Etiology

Metabolomic identification of α-ketoglutaric acid elevation in pediatric chronic graft-versus-host disease.
Subburaj D, Ng B, Kariminia A, Abdossamadi S, Lauener M, Nemecek ER, Rozmus J, Kharbanda S, Kitko CL, Lewis VA, Schechter-Finklestein T, Jacobsohn DA, Harris AC, Pulsipher MA, Bittencourt H, Choi SW, Caywood EH, Kasow KA, Bhatia M, Oshrine BR, Coulter D, Chewning JH, Joyce M, Pawlowska AB, Megason GC, Lawitschka A, Ostroumov E, Klein Geltink R, Cuvelier GDE, Schultz KR
Blood 2022 Jan 13;139(2):287-299. doi: 10.1182/blood.2021013244. PMID: 34534280
Extracorporeal photopheresis as first-line strategy in the treatment of acute graft-versus-host disease after hematopoietic stem cell transplantation: A single-center experience.
Sestili S, Eder S, Belhocine R, Dulery R, Battipaglia G, Brissot E, Mediavilla C, Banet A, van de Wyngaert Z, Paviglianiti A, Ledraa T, Bonin A, Mohty M, Malard F
Cytotherapy 2020 Aug;22(8):445-449. Epub 2020 May 18 doi: 10.1016/j.jcyt.2020.03.003. PMID: 32434750
IL6-receptor antibody tocilizumab as salvage therapy in severe chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: a retrospective analysis.
Kattner AS, Holler E, Holler B, Klobuch S, Weber D, Martinovic D, Edinger M, Herr W, Wolff D
Ann Hematol 2020 Apr;99(4):847-853. Epub 2020 Feb 21 doi: 10.1007/s00277-020-03968-w. PMID: 32086584Free PMC Article
Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease.
Koreth J, Kim HT, Jones KT, Lange PB, Reynolds CG, Chammas MJ, Dusenbury K, Whangbo J, Nikiforow S, Alyea EP 3rd, Armand P, Cutler CS, Ho VT, Chen YB, Avigan D, Blazar BR, Antin JH, Ritz J, Soiffer RJ
Blood 2016 Jul 7;128(1):130-7. Epub 2016 Apr 12 doi: 10.1182/blood-2016-02-702852. PMID: 27073224Free PMC Article
TLI in refractory chronic GVHD.
Devillier R, Castagna L, Gonzague L, El-Cheikh J, Fürst S, Faucher C, Michel R, Blaise D
Bone Marrow Transplant 2013 Jun;48(6):854-8. Epub 2012 Dec 10 doi: 10.1038/bmt.2012.240. PMID: 23222383

Diagnosis

Metabolomic identification of α-ketoglutaric acid elevation in pediatric chronic graft-versus-host disease.
Subburaj D, Ng B, Kariminia A, Abdossamadi S, Lauener M, Nemecek ER, Rozmus J, Kharbanda S, Kitko CL, Lewis VA, Schechter-Finklestein T, Jacobsohn DA, Harris AC, Pulsipher MA, Bittencourt H, Choi SW, Caywood EH, Kasow KA, Bhatia M, Oshrine BR, Coulter D, Chewning JH, Joyce M, Pawlowska AB, Megason GC, Lawitschka A, Ostroumov E, Klein Geltink R, Cuvelier GDE, Schultz KR
Blood 2022 Jan 13;139(2):287-299. doi: 10.1182/blood.2021013244. PMID: 34534280

Therapy

Metabolomic identification of α-ketoglutaric acid elevation in pediatric chronic graft-versus-host disease.
Subburaj D, Ng B, Kariminia A, Abdossamadi S, Lauener M, Nemecek ER, Rozmus J, Kharbanda S, Kitko CL, Lewis VA, Schechter-Finklestein T, Jacobsohn DA, Harris AC, Pulsipher MA, Bittencourt H, Choi SW, Caywood EH, Kasow KA, Bhatia M, Oshrine BR, Coulter D, Chewning JH, Joyce M, Pawlowska AB, Megason GC, Lawitschka A, Ostroumov E, Klein Geltink R, Cuvelier GDE, Schultz KR
Blood 2022 Jan 13;139(2):287-299. doi: 10.1182/blood.2021013244. PMID: 34534280
IL6-receptor antibody tocilizumab as salvage therapy in severe chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: a retrospective analysis.
Kattner AS, Holler E, Holler B, Klobuch S, Weber D, Martinovic D, Edinger M, Herr W, Wolff D
Ann Hematol 2020 Apr;99(4):847-853. Epub 2020 Feb 21 doi: 10.1007/s00277-020-03968-w. PMID: 32086584Free PMC Article
Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease.
Koreth J, Kim HT, Jones KT, Lange PB, Reynolds CG, Chammas MJ, Dusenbury K, Whangbo J, Nikiforow S, Alyea EP 3rd, Armand P, Cutler CS, Ho VT, Chen YB, Avigan D, Blazar BR, Antin JH, Ritz J, Soiffer RJ
Blood 2016 Jul 7;128(1):130-7. Epub 2016 Apr 12 doi: 10.1182/blood-2016-02-702852. PMID: 27073224Free PMC Article
TLI in refractory chronic GVHD.
Devillier R, Castagna L, Gonzague L, El-Cheikh J, Fürst S, Faucher C, Michel R, Blaise D
Bone Marrow Transplant 2013 Jun;48(6):854-8. Epub 2012 Dec 10 doi: 10.1038/bmt.2012.240. PMID: 23222383
Rapamycin (sirolimus) for treatment of chronic graft-versus-host disease.
Johnston LJ, Brown J, Shizuru JA, Stockerl-Goldstein KE, Stuart MJ, Blume KG, Negrin RS, Chao NJ
Biol Blood Marrow Transplant 2005 Jan;11(1):47-55. doi: 10.1016/j.bbmt.2004.10.004. PMID: 15625544

Prognosis

IL6-receptor antibody tocilizumab as salvage therapy in severe chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: a retrospective analysis.
Kattner AS, Holler E, Holler B, Klobuch S, Weber D, Martinovic D, Edinger M, Herr W, Wolff D
Ann Hematol 2020 Apr;99(4):847-853. Epub 2020 Feb 21 doi: 10.1007/s00277-020-03968-w. PMID: 32086584Free PMC Article
Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease.
Koreth J, Kim HT, Jones KT, Lange PB, Reynolds CG, Chammas MJ, Dusenbury K, Whangbo J, Nikiforow S, Alyea EP 3rd, Armand P, Cutler CS, Ho VT, Chen YB, Avigan D, Blazar BR, Antin JH, Ritz J, Soiffer RJ
Blood 2016 Jul 7;128(1):130-7. Epub 2016 Apr 12 doi: 10.1182/blood-2016-02-702852. PMID: 27073224Free PMC Article
TLI in refractory chronic GVHD.
Devillier R, Castagna L, Gonzague L, El-Cheikh J, Fürst S, Faucher C, Michel R, Blaise D
Bone Marrow Transplant 2013 Jun;48(6):854-8. Epub 2012 Dec 10 doi: 10.1038/bmt.2012.240. PMID: 23222383
Rapamycin (sirolimus) for treatment of chronic graft-versus-host disease.
Johnston LJ, Brown J, Shizuru JA, Stockerl-Goldstein KE, Stuart MJ, Blume KG, Negrin RS, Chao NJ
Biol Blood Marrow Transplant 2005 Jan;11(1):47-55. doi: 10.1016/j.bbmt.2004.10.004. PMID: 15625544

Clinical prediction guides

Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease.
Koreth J, Kim HT, Jones KT, Lange PB, Reynolds CG, Chammas MJ, Dusenbury K, Whangbo J, Nikiforow S, Alyea EP 3rd, Armand P, Cutler CS, Ho VT, Chen YB, Avigan D, Blazar BR, Antin JH, Ritz J, Soiffer RJ
Blood 2016 Jul 7;128(1):130-7. Epub 2016 Apr 12 doi: 10.1182/blood-2016-02-702852. PMID: 27073224Free PMC Article

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